Comments on: Does Rogaine Cause Wrinkles? http://www.savvyskin.com/does-rogaine-cause-wrinkles Anti-aging skin care secrets to fabulous, smooth, glowing skin! Fri, 23 Dec 2011 12:09:38 +0000 http://wordpress.org/?v=4838 hourly 1 By: Anth http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-117872 Anth Tue, 13 Dec 2011 01:22:59 +0000 http://www.savvyskin.com/?p=824#comment-117872 After two months, I am noticing my skin looking a bit haggard. Skin around eyes has become a little saggy, and minor dark circles have formed. Im going to stop Minox. after I finish this last bottle and switch to Propecia. After two months, I am noticing my skin looking a bit haggard. Skin around eyes has become a little saggy, and minor dark circles have formed. Im going to stop Minox. after I finish this last bottle and switch to Propecia.

]]> By: dave http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-117332 dave Mon, 05 Dec 2011 07:53:29 +0000 http://www.savvyskin.com/?p=824#comment-117332 just shave your head.. the ladies love it.. just shave your head.. the ladies love it..

]]> By: Gillian http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-114145 Gillian Sun, 16 Oct 2011 19:40:38 +0000 http://www.savvyskin.com/?p=824#comment-114145 I tried 5% foam for six weeks when I did start noticing skin effects - suddenly I was developing wrinkles under my eyes and my skin didn't look all that healthy. I stopped and those wrinkles went away. I decided to discontinue Rogaine. I wore a hairpiece instead. I wasn't about to pay to look older and haggard. I tried 5% foam for six weeks when I did start noticing skin effects – suddenly I was developing wrinkles under my eyes and my skin didn’t look all that healthy. I stopped and those wrinkles went away. I decided to discontinue Rogaine. I wore a hairpiece instead. I wasn’t about to pay to look older and haggard.

]]> By: Connie http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-112412 Connie Sun, 11 Sep 2011 10:13:35 +0000 http://www.savvyskin.com/?p=824#comment-112412 I used it for 4 or 5 months and I started to see serious bags under my eyes and my skin was not looking so hot. I quit yesterday. I'm now trying to get rid of the bags by using Vitamin E. I'm so mad about this shit because I never had bags under my eyes until I started using this garbage. They tell you all you get is a dry scalp but that's not a lie. I knew it was too good to be true! Find another way to get your hair to grow back, cause using Rogaine is not worth it! I used it for 4 or 5 months and I started to see serious bags under my eyes and my skin was not looking so hot. I quit yesterday. I’m now trying to get rid of the bags by using Vitamin E. I’m so mad about this shit because I never had bags under my eyes until I started using this garbage. They tell you all you get is a dry scalp but that’s not a lie. I knew it was too good to be true! Find another way to get your hair to grow back, cause using Rogaine is not worth it!

]]> By: Skin care in delhi-Clinic Dermatech http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-111852 Skin care in delhi-Clinic Dermatech Fri, 26 Aug 2011 10:13:16 +0000 http://www.savvyskin.com/?p=824#comment-111852 Rogaine does affect your skin & cause Wrinkles on the face of a person. Rogaine does affect your skin & cause Wrinkles on the face of a person.

]]> By: Moi http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-110396 Moi Thu, 28 Jul 2011 22:52:02 +0000 http://www.savvyskin.com/?p=824#comment-110396 I used Rogaine 5% foam and it ruined my face. I always had youthful skin, but this made my eyes puffy, my pores gaping, my skin haggard. I quit and I am looking much healthier again. It doesn't happen to everyone. You won't know until you try. I used Rogaine 5% foam and it ruined my face. I always had youthful skin, but this made my eyes puffy, my pores gaping, my skin haggard. I quit and I am looking much healthier again. It doesn’t happen to everyone. You won’t know until you try.

]]> By: B http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-109130 B Mon, 04 Jul 2011 23:16:02 +0000 http://www.savvyskin.com/?p=824#comment-109130 Be reassured: I have begun using topical Rogaine, and have looked into the details. The levels you get from topical use are much lower than the oral dose and are 2 ng/mL or lower (which = 0.0095 uMol/L) even at the 5% dose, and even with multiple daily applications. [Ref: AHFS Monograph, Medscape on Minoxidil topical pharmacokinetics] Meanwhile, the minimum dose required to suppress lysyl hydroxylase in fibroblasts (the cells and enzyme it inhibits in collagen synthesis) is 25 uMol/L (Br J Derm 2004; 150, 186-194) or over 2600 times the blood concentration you develop. Even very rare individuals who have abnormally high absorption through skin found to have 30ng/mL in the blood would still need 173 times the concentration they have to inhibit collagen synthesis in skin fibroblasts. And remember, skin concentrations outside of the area of application don't have the level of drug found in the blood. This is further evidenced by the fact that when dermatologists initially saw a few studies noting such collagen effects, it was theorized that direct application of minoxidil onto skin might help prevent scarring from collagen formation. Minoxidil failed to prevent such scarring from collagen formation, even where minoxidil was directly applied, because in part it is believed to inhibit a version of the enzyme which is not as critical to collagen cross linking in the first place. (http://www.ncbi.nlm.nih.gov/pubmed/15908192) Be reassured: I have begun using topical Rogaine, and have looked into the details. The levels you get from topical use are much lower than the oral dose and are 2 ng/mL or lower (which = 0.0095 uMol/L) even at the 5% dose, and even with multiple daily applications. [Ref: AHFS Monograph, Medscape on Minoxidil topical pharmacokinetics]

Meanwhile, the minimum dose required to suppress lysyl hydroxylase in fibroblasts (the cells and enzyme it inhibits in collagen synthesis) is 25 uMol/L (Br J Derm 2004; 150, 186-194) or over 2600 times the blood concentration you develop.

Even very rare individuals who have abnormally high absorption through skin found to have 30ng/mL in the blood would still need 173 times the concentration they have to inhibit collagen synthesis in skin fibroblasts. And remember, skin concentrations outside of the area of application don’t have the level of drug found in the blood.

This is further evidenced by the fact that when dermatologists initially saw a few studies noting such collagen effects, it was theorized that direct application of minoxidil onto skin might help prevent scarring from collagen formation. Minoxidil failed to prevent such scarring from collagen formation, even where minoxidil was directly applied, because in part it is believed to inhibit a version of the enzyme which is not as critical to collagen cross linking in the first place. (http://www.ncbi.nlm.nih.gov/pubmed/15908192)

]]> By: Janti Basu http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-107164 Janti Basu Wed, 08 Jun 2011 11:04:33 +0000 http://www.savvyskin.com/?p=824#comment-107164 After Minoxidil hair tonic my skins pores became enlarged and dark rings formed around my eyes. 2 years later and this is still there and wrinkles. After Minoxidil hair tonic my skins pores became enlarged and dark rings formed around my eyes. 2 years later and this is still there and wrinkles.

]]> By: Jeni - Savvy Skin http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-98585 Jeni - Savvy Skin Mon, 14 Mar 2011 03:45:04 +0000 http://www.savvyskin.com/?p=824#comment-98585 Samuel, I haven't ever heard of propylene glycol causing wrinkles, but I know it does cause an allergic reaction for some people, so it's good to know the foam version of Rogaine doesn't contain that ingredient. From what I've read, it's the actual active ingredient minoxidil, though, that is the wrinkle-causing culprit. Samuel,
I haven’t ever heard of propylene glycol causing wrinkles, but I know it does cause an allergic reaction for some people, so it’s good to know the foam version of Rogaine doesn’t contain that ingredient. From what I’ve read, it’s the actual active ingredient minoxidil, though, that is the wrinkle-causing culprit.

]]> By: Samuel http://www.savvyskin.com/does-rogaine-cause-wrinkles/comment-page-1#comment-98542 Samuel Sun, 13 Mar 2011 19:53:00 +0000 http://www.savvyskin.com/?p=824#comment-98542 Have you ladies tried the foam formula. The foam formula does not contain propylene glycol which happens to be a skin irritant and can cause wrinkles as the greasy formula runs down your face. The foam is (http://www.answerbag.com/q_view/1936835) propylene glycol free and you can probably avoid the skin problems, not sure if you can stay away from the itchy scalp issue though. Have you ladies tried the foam formula. The foam formula does not contain propylene glycol which happens to be a skin irritant and can cause wrinkles as the greasy formula runs down your face. The foam is (http://www.answerbag.com/q_view/1936835) propylene glycol free and you can probably avoid the skin problems, not sure if you can stay away from the itchy scalp issue though.

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